C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 59/64 (2006.01) C07C 51/377 (2006.01) C07C 51/41 (2006.01) C07C 67/297 (2006.01) C07C 69/734 (2006.01)
Patent
CA 2392032
The present invention relates to novel resolution methods, which are useful in the preparation of enantiomerically enriched intermediates which in their turn are useful in the prepartion of compounds with a pharmacological effect on the insulin resistance syndrome (IRS). It is such a process that the present inventions sets out to define, and more particularly for the preparation of the (S)-enantioner of certain 2-ethoxy-3-(4-hydroxyphenyl)propanoic acids and derivatives thereof.
L'invention concerne des nouveaux procédés de résolution utiles dans la préparation d'intermédiaires à excès énantionère supérieur à 50 %, lesquels sont à leur tour utiles dans la préparation de composés ayant un effet pharmaceutique sur le syndrome de résistance à l'insuline. Elle porte notamment sur un procédé de préparation du (<I>S</I>)-énantiomère de certains acides 2-éthoxy-3-(4-hydroxyphényl)propanoïques et leurs dérivés.
Andersson Kjell
Fischer Alan Eric
Ioannidis Panagiotis
Larsson Magnus
Larsson Maria
Astrazeneca Ab
Fetherstonhaugh & Co.
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