C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/86 (2006.01) A61K 31/4412 (2006.01) A61P 7/02 (2006.01)
Patent
CA 2553604
There is provided a compound of formula I, wherein the dashed line, R1, R2, R3a, R3b, A, D, E, G and L have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e.g. conditions, such as thrombo-embolisms, where inhibition of thrombin is required or desired, and/or conditions where anticoagulant therapy is indicated).
L'invention concerne un composé ayant la formule I, dans laquelle la ligne tiretée, R?1¿, R?2¿, R?3a¿, R?3b¿, A, D, E, G et L ont des valeurs indiquées dans le descriptif, ces composés étant utiles en tant que promédicaments, inhibiteurs compétitifs de protéases de type trypsine telle que la thrombine, et notamment dans le traitement d'états dans lesquels l'inhibition de la thrombine peut être bénéfique (à savoir d'états tels que les thrombo-embolismes lorsque l'inhibition de la thrombine est requise ou désirée, et/ou d'états dans lesquels une thérapie par anticoagulants est indiquée).
Bayrakdarian Malken
Berggren Kristina
Davidsson Oejvind
Fjellstroem Ola
Gustafsson David
Astrazeneca Ab
Fetherstonhaugh & Co.
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