New pyridine derivatives as leukcotriene b antagonists

Details New pyridine derivatives as leukcotriene b antagonists New pyridine derivatives as leukcotriene b antagonists

C - Chemistry, Metallurgy

07

D

C07D 213/65 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 213/55 (2006.01) C07D 213/61 (2006.01) C07D 401/06 (2006.01) C07D 405/12 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2139586

The invention pertains to new pyridine derivatives of formula (I) where ??? denotes a single bond or a double bond, m, n, p and r in each case stands for a number from 0 to 5, q is 1 or 2, U denotes a single bond or the grouping -CH2-CH2-, -CHOH-, - CO- -CH = CH-, -C ? C-, -CO-CO- or -CHOH-CHOH-, V stands for a single bond, phenyl residue or pyridyle residue, W is a hydrogen atom, a halogen atom, and alkyl group with up to four carbon atoms, a trifluoromethyl group, and alkylsulfonylamino group, a trifluoromethylsulfonylamino group, an arylsulfonylaminocarbonyl group, a free, esterified or amidated carboxyl group, or a hydroxy group, X denotes a free esterified or amidated carboxyl group, Y is an oxygen atom or a methylene group, and Z is a single bond if q is 2 or otherwise an alkyl group or alkylene group with at most 8 carbon atoms or a phenyl, phenoxy or styryl residue substituted by alkyl groups with at most 4 carbon atoms, alkoxy groups with at most 4 carbon atoms, 1-oxoalkyl groups with at most 4 carbon atoms, halogen atoms and/or trifluoromethyl groups. The invention also concerns salts of these derivatives with bases which are generally recognized as physiologically safe.

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