New substituted nitrogen-containing heterobicycles, the...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 403/14 (2006.01) A61K 31/4709 (2006.01) A61K 31/517 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2511349

The invention relates to novel substituted nitrogen-containing heterobicycles of general formula (I), wherein B, X1 to X3, and R1 to R5 are defined as indicated in claim 1, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of said general formula (I) and the tautomers, enantiomers, diastereomers, mixtures, and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids or bases, and the stereoisomers thereof have valuable pharmaceutical properties, especially an antithrombotic effect and a factor Xa-inhibiting effect.

L'invention concerne de nouveaux composés hétérocycliques azotés substitués de formule générale (I), dans laquelle B, X?1¿ à X?3¿ et R?1¿ à R?5¿ sont tels que définis dans la revendication n·1, ainsi que leurs tautomères, énantiomères, diastéréoisomères, mélanges et sels, en particulier leurs sels physiologiquement tolérables contenant des acides ou des bases inorganiques ou organiques, ces composés présentant des propriétés intéressantes. Les composés de formule générale (I) et leurs tautomères, énantiomères, diastéréoisomères, mélanges et sels, en particulier leurs sels physiologiquement tolérables contenant des acides ou des bases inorganiques ou organiques, ainsi que leurs stéréoisomères présentent des propriétés pharmacologiques intéressantes, notamment un effet antithrombotique et un effet d'inhibition du facteur Xa.

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