C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/58 (2006.01) A61K 31/00 (2006.01) A61K 31/195 (2006.01)
Patent
CA 2432121
The compound of formula (I): (see formula I) namely (2S)-2-amino-4-{[2-(ethanimidoylamino)ethyl]thio}butanoic acid, compound with phosphoric acid, or a hydrate thereof, is useful as a relatively non- hygroscopic selective inhibitor of inducible nitric oxide synthase; previously identified salt forms of (2S)-2- amino-4-{[2- ethanimidoylamino)ethyl]thio}butanoic acid are known to be hygroscopic. The compound of formula (I) or a hydrate thereof does not readily absorb moisture from the atmosphere, is easier to isolate, formulate and handle, and finds use in the prophylaxis or treatment of clinical conditions such as arthritis, asthma, rhinitis, an inflammatory condition or immune disorder of the skin, an inflammatory condition or immune disorder of the eye, ileus, migraine, pain and irritable bowel syndrome.
L'invention concerne un composé représenté par la formule (I), à savoir: composé d'addition, avec acide (2S)-2-amino-4-{[2-(éthanimidoylamino)éthyl]thio}butyrique, et composé à l'acide phosphorique. Il peut également s'agir d'un solvate ou d'un dérivé physiologiquement fonctionnel correspondant. Le composé considéré est utile comme inhibiteur sélectif relativement non hygroscopique d'oxyde nitrique synthase pouvant être induite.
Box David
Colclough David
Gillies Iain
Loft Michael Simon
Moore Rebecca
Glaxo Group Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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