Nitric oxide synthase inhibitors derived from cyclic amidines

Details Nitric oxide synthase inhibitors derived from cyclic amidines Nitric oxide synthase inhibitors derived from cyclic amidines

C - Chemistry, Metallurgy

07

D

C07D 223/12 (2006.01) A61K 31/395 (2006.01) A61K 31/675 (2006.01) C07D 207/22 (2006.01) C07D 207/24 (2006.01) C07D 211/72 (2006.01) C07D 211/74 (2006.01) C07D 243/08 (2006.01) C07D 267/10 (2006.01) C07D 281/06 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 403/06 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 417/00 (2006.01) C07D 471/10 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2218360

Compounds having formula (I) wherein R1, R5, R6 and R7 are hydrogen or certain specified substituents; R8 and R9 are independently hydrogen, hydroxy or alkoxy; and X, A and B are independently NR2, O, S, SO, SO2, CH=CH or (CH2)p, p being 0-6; are useful as nitric oxide synthase inhibitors.

L'invention concerne les composés présentant la formule (I) dans laquelle, R?1¿, R?5¿, R?6¿ et R?7¿ sont de l'hydrogène ou des substituants spécifiés; R?8¿ et R?9¿ sont indépendamment de l'hydrogène, de l'hydroxy ou de l'alkoxy; et X, A et B sont indépendamment du NR?2¿, O, S, SO, SO¿2?, CH=CH ou (CH¿2?)p, p étant compris entre 0 et 6. Ces composés peuvent être utilisés comme inhibiteurs de la synthase d'oxyde nitrique.

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