Nitrogen-containing 5-membered ring compound

Details Nitrogen-containing 5-membered ring compound Nitrogen-containing 5-membered ring compound

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/401 (2006.01) A61K 31/4025 (2006.01) A61K 31/4035 (2006.01) A61K 31/4178 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/437 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01) C07D 207/16 (2006.01) C07D 207/404 (2006.01) C07D 207/416 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07

Patent

CA 2424964

The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: (see formula I) wherein symbols in the formula have the following meanings; A: -CH2- or -S-, B: CH or N, R1: H, a lower alkyl group, etc., X: a single bonding arm, -CO-, -Alk-CO-, -COCH2-, -Alk-O-, -O-CH2-, -SO2-, -S-, -COO-, -CON(R3)-, -Alk-CON(R3)-, -CON(R3)CH2-, -NHCH2-, etc., R3: hydrogen atom or a lower alkyl group, Alk: a lower alkylene group, and R2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is -CO-, then B is N, or a pharmaceutically acceptable salt thereof. The compound have superior dipeptidylpeptidase IV inhibitory action.

L'invention concerne des composés aliphatiques azotés à noyau à cinq éléments représentés par la formule (I) ou des sels de ceux-ci pharmaceutiquement acceptables. Dans cette formule, A représente -CH2- ou -S-; B représente CH ou N; R1 représente H, alkyle inférieur ou analogue; X représente une seule liaison, -CO-, -Alk-CO-, -COCH2-, -Alk-O-, -O-CH2-, -SO2-, -S-, -COO-, -CON(R3)-, -Alk-CON(R3)-, -CON(R3)CH2-, -NHCH2-, ou analogue; R3 représente H ou alkyle inférieur; Alk représente alkylène inférieur; et R2 représente un groupe cyclique éventuellement substitué, un amino substitué, ou analogue, à condition que lorsque X représente -CO-, B représente N.

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