C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4155 (2006.01) A61K 31/4164 (2006.01) A61K 31/4184 (2006.01) A61K 31/427 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/502 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 31/18 (2006.01) C07D 207/335 (2006.01) C07D 213/38 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 215/40 (2006.01) C07D 233/02 (2006.01
Patent
CA 2405690
Novel nitrogenous compounds having antiviral activities, and antiviral drugs containing the compounds as the active ingredient. The compounds are representatively those of the general formula (|): (|) wherein A1 and A2 are each guanidino or a group of the general formula (ia); A3 is a mono- or poly- cyclic heteroaromatic ring group containing 1 or 2 heteroatoms; B1 is a single bond or alkylene; R1 is hydrogen or alkyl; W is C2-3 alkylene, C5-10 cycloalkylene, a C6-10 aromatic ring or a C5-10 heteroaromatic ring; y is C(=O)-; x is C(=O)-NH-; n1 is an integer of 1 to 2; n2 is an integer of 2 to 3; and D is a substituent selected from among various groups. (ia)
L'invention concerne de nouveaux composés azotés à activité antivirale, et des médicaments antiviraux contenant ces composés comme ingrédients actifs. Les composés sont répresentés par la formule générale (I) dans laquelle A?1¿ et A?2¿ sont chacun guanidino ou un groupe représenté par la formule générale (ia) ; A?3¿ est un groupe à noyau hétéroaromatique monocyclique ou polycyclique contenant 1 ou 2 hétéroatomes; B?1 ¿est une liaison simple ou alcoylène ; R?1¿ est hydrogène ou alkyle ; W est alcoylène C¿2-3?, cycloalcoylène C¿5-10?, un noyau aromatique C¿6-10 ?ou un noyau hétéroaromatique C¿5-10?; y est -C(=O)- ; x est -C(=O)-NH- ; n?1¿ est un entier de 1 à 2 ; n?2¿ est un entier de 2 à 3 ; et D est un substituant sélectionné parmi divers groupes.
Hirose Kunitaka
Maruoka Hiroshi
Mukade Tsutomu
Suzuki Shigeru
Yamamoto Naoki
Dennison Associates
Kureha Chemical Industry Company Limited
Kureha Corporation
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