Nitrosourea compounds and process for preparing the same

C - Chemistry – Metallurgy – 07 – H

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C07H 15/12 (2006.01) C07C 275/68 (2006.01) C07H 13/12 (2006.01)

Patent

CA 1097624

ABSTRACT OF THE DISCLOSURE A nitrosoures compound of the formula: Image wherein R1 is alkyl of one to six carbon atoms, hydroxyalkyl of one to six carbon atoms, alkenyl of three to five carbon atoms or alkynyl of three to five carbon atoms, R2 is aldo- pentofuranosyl, aldo-pentopyranosyl, aldo-hexopyranosyl, O- aldo-hexopyranosyl-(1?4)-aldo-hexopyranosyl, or a group of the formula: -CH2(CHOH)nCH2OH, and n is an integer of zero or one to four, is prepared by nitrosation of a compound of the formula: Image wherein R1 and R2 are the same as above. Said nitrosourea compound is useful as an anti-tumor or anti-leukemic agent.

307987

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