Nmr spectroscopic in vitro assay using hyperpolarization

Details Nmr spectroscopic in vitro assay using hyperpolarization Nmr spectroscopic in vitro assay using hyperpolarization

G - Physics

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G01R 33/465 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/58 (2006.01) G01R 33/30 (2006.01) G01N 24/08 (2006.01)

Patent

CA 2356442

An in vitro assay method which comprises the use of an assay reagent containing at least one NMR active nucleus, and hyperpolarising at least one NMR active nucleus of the assay reagent; and analysing the assay reagent and/or the assay by NMR spectroscopy and/or NMR imaging. The assay reagent may contain an artificially high concentration of an NMR active nucleus.

L'invention porte sur un procédé relatif à un essai in vitro consistant à utiliser au moins un réactif d'essai contenant au moins un noyau sensible à la RMN, puis à hyperpolariser au moins l'un de ces noyaux, puis à analyser ledit réactif et/ou ou l'essai par spectroscopie RMN ou imagerie RMN, le réactif de l'essai pouvant contenir une concentration artificiellement élevée de noyaux sensibles à la RMN.

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