C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 225/22 (2006.01) A61K 31/341 (2006.01) A61K 31/44 (2006.01) C07C 221/00 (2006.01) C07C 227/00 (2006.01) C07C 229/60 (2006.01) C07D 211/06 (2006.01) C07D 307/52 (2006.01)
Patent
CA 2616910
Non-steroidal androgen receptor modulating compounds of the general formula (I), their pharmaceutically acceptable salts, preparation process and pharmaceutically compositions containing the said compounds are disclosed. Such compounds of the general formula (I) or their pharmaceutically acceptable salts can be used for preparing non-steroidal medicines to treat and/or prevent condictions or diseases such as prostatic hyperplasia, prostate cancer, hirsutism, severe hormone-dependent alopecia or acne, etc. as a result of androgen receptor antagonistic activities. (see formula I)
La présente invention concerne des composés régulateurs des accepteurs d'androgènes non stéroïdiens répondant à la formule générale (I), leurs sels pharmaceutiquement acceptables, un procédé de préparation et des compositions pharmaceutiques contenant lesdits composés. De tels composés répondant à la formule générale (I) ou leurs sels phamaceutiquement acceptables peuvent être utilisés pour la préparation de médicaments non stéroïdiens en vue de traiter et/ou de prévenir des états ou des maladies tels que l'hyperplasie prostatique, le cancer de la prostate, l'hirsutisme, l'alopécie hautement hormono-dépendante et Cane et al. à cause de l'activité antagoniste des accepteurs d'androgènes.
Deng Yong
Gao Jie
Hui Xin
Su Haoran
Wang Mingwei
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
Sichuan University
Smart & Biggar
LandOfFree
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