Non-toxic immunogens derived from a retroviral regulatory...

Details Non-toxic immunogens derived from a retroviral regulatory... Non-toxic immunogens derived from a retroviral regulatory...

C - Chemistry, Metallurgy

07

K

C07K 14/155 (2006.01) A61K 39/21 (2006.01) A61K 39/39 (2006.01) A61K 39/42 (2006.01) C07K 7/08 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2215483

An immunogenic compound that, being non-toxic, may be administered to humans, and is derived from an HIV-1, HIV-2, HTLV-1 or HTLV-2 virus regulatory protein by chemical processing using a coupling agent such as an aldehyde, or from a carrier protein activated by pre-processing using an aldehyde, whereby said compound may be recognised by antibodies to said regulatory protein, and retain sufficient immunogenic properties to produce antibodies that neutralise or block the native protein, while losing at least 50 % of the toxic biological properties of said native protein.

Composé immunogène administrable à l'homme car dénué de toxicité, dérivant d'une protéine de régulation d'un virus VIH-1, VIH-2, HTLV-1 ou HTLV-2, par traitement chimique à l'aide d'un agent de couplage tel qu'un aldéhyde, ou d'une protéine porteuse activée par un pré-traitement à l'aide d'un aldhéhyde, lui permettant d'êtrereconnu par des anticorps dirigés contre ladite protéine de régulation, et de conserver des propriétes immunogènes suffisantes pour créer des anticorps neutralisant ou bloquant ladite protéine native, tout en ayant perdu au mois 50 % des propriétés biologiques toxiques de ladite protéine native.

Affiliated with

Also associated with

Rating

Non-toxic immunogens derived from a retroviral regulatory... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-toxic immunogens derived from a retroviral regulatory..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-toxic immunogens derived from a retroviral regulatory... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1687726