C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 63/00 (2006.01) A61K 31/575 (2006.01) A61P 31/18 (2006.01) C07J 53/00 (2006.01)
Patent
CA 2714049
The invention relates to 17.beta. lupane derivatives of formula (I): wherein R1 and X are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infection by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
L'invention porte sur des dérivés de 17ß-lupane de formule (I) : dans laquelle R1 et X sont tels que définis dans la description, et sur les sels pharmaceutiquement acceptables et solvates de ceux-ci. Ces composés présentent une activité significative anti-VIH. Ainsi, l'invention porte également sur des procédés de prévention ou de traitement d'une infection à VIH par administration de quantités thérapeutiquement efficaces d'un composé de formule (I), ou d'un sel pharmaceutiquement acceptable ou solvate de ceux-ci, à un sujet ayant besoin d'un tel traitement.
Bubenik Monica
Chan Chun Kong Laval
Denis Real
Halab Liliane
Liu Bingcan
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Virochem Pharma Inc.
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