C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/351 (2006.01) A61K 31/381 (2006.01) A61K 31/506 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2614597
The invention relates to products of formula (I) in which: R2, R3 and R4 represent one hydrogen and the others represent hydrogen, halogen, alkyl or alkoxy; R5 represents hydrogen or halogen; R1 represents hydrogen, cycloalkyl, alkyl, alkenyl or alkynyl, all of which being optionally substituted; A represents a single bond or -CH2-CO-NR6- with R6 being selected among the values of R1; the cycle containing Y (or (Y) cycle)) having 4 to 8 members with Y representing O, S, SO, SO2, N-R7 ((Y) cycle) that can contain a carbon bridge), C=O or the dioxolane therefor, CF2, CH-OR8, CH-NR8R9, and; R7 represents hydrogen, cycloalkyl, alkyl, CH2-alkenyl or CH2-alkynyl, all of which being optionally substituted; R8 represents hydrogen, alkyl, cycloalkyl or heterocycloalkyl, all of which being optionally substituted, these products existing in all isomeric forms and the salts. The invention also relates to the use of the aforementioned derivatives as medicaments, in particular, as IKK inhibitors.
L'invention concerne les produits de formule (I) dans laquelle R2, R3 et R4 représentent l'un hydrogène et les autres hydrogène, halogène, alkyle ou alcoxy; R5 représente hydrogêne ou halogène; Rl représente hydrogène, cycloalkyle, alkyle, alkényle ou alkynyle, tous éventuellement substitués ; A représente simple liaison ou -CH2-CO-NR6- avec R6 est choisi parmi les valeurs de Rl; le cycle renfermant Y (ou cycle (Y) ) ayant 4 à 8 chaînons avec Y représente O, S, SO, SO2 , N-R7 (cycle (Y) pouvant renfermant un pont carboné) , C=O ou son dioxolanne, CF2 , CH-0R8, CH-NR8R9 ; et R7 représente hydrogène, cycloalkyle, alkyle, CH2 -alkényle ou CH2- alkynyle, éventuellement substitués ; R8 représente hydrogène, alkyle, cycloalkyle ou hétérocycloalkyle éventuellement substitués,- ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments notamment comme inhibiteurs de IKK.
Bosch Michael
Bouaboula Monsif
Casellas Pierre
Jegham Samir
Mignani Serge
Robic
Sanofi-Aventis
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