Novel 3-(4-oxo-40-chromen-2-yl)-(1h)-quinoline-4-one...

Details Novel 3-(4-oxo-40-chromen-2-yl)-(1h)-quinoline-4-one... Novel 3-(4-oxo-40-chromen-2-yl)-(1h)-quinoline-4-one...

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2489136

The invention concerns a compound of formula (I), wherein: R¿1?, R¿2?, R¿3?, R¿4?, R¿6?, R¿8?, R¿9? and R¿10?, identical or different, represent each a group selected among hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR' wherein R' represents an ionized or ionizable group; R¿5? represents a group selected among alkyl, aryl and heteroaryl; R¿7? represents a group selected among hydrogen, hydroxy, alkoxy, alkyle and cycloalkyl, or R¿7? represents a nitrogenous or oxygen-containing heterocyle, its optical isomers, if any, its hydrates, its solvates and its addition salts to a pharmaceutically acceptable acid.

Composé de Formule (I) dans laquelle : R1, R2, R3, R4, R6, R8, R9 et R10, identiques ou différents, représentent chacun un groupement choisi parmi hydrogène, hydroxy, alkoxy, alkyle, arylalkoxy, alkoxycarbonylalkoxy et OR' dans lequel R' représente un groupement ionise ou ionisable, R5 représente un groupement choisi parmi alkyle, aryle et heteroaryle, R7 représente un groupement choisi parmi hydrogène, hydroxy, alkoxy, alkyle et cycloalkyle, ou bien R7 représente un hétérocycle azoté ou oxygèné, ses isomères optiques lorsqu'ils existent, ses hydrates, ses solvates ainsi que ses sels d~addition à un acide pharmaceutiquement acceptable.

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