Novel 4,6-diarylpyrimidine derivatives and salts thereof

Details Novel 4,6-diarylpyrimidine derivatives and salts thereof Novel 4,6-diarylpyrimidine derivatives and salts thereof

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) C07D 401/04 (2006.01) C07D 403/02 (2006.01) C07D 403/12 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 521/00 (2006.01) C07F 9/6512 (2006.01)

Patent

CA 2190973

Described are a 4,6-diarylpyrimidine derivative represented by the following formula (1): (see formula) wherein R represents a heterocyclic ring which may be substituted by one to four lower alkyl groups or an amino group and Ar represents a phenyl, naphthyl or aromatic heterocyclic group which may have one to four substituents, and a salt thereof; a preparation process therefor; and a pharmaceutical containing it as an effective ingredient. It has excellent neovascular inhibitory action and is useful as a therapeutic agent for solid cancer, rheumatism, diabetic retinopathy or psoriasis.

L'invention concerne de nouveaux dérivés 4,6-diarylpyrimidine représentés par la formule générale (1), leurs sels et un procédé pour les produire, ainsi que des médicaments contenant ces dérivés en tant qu'ingrédients actifs. Dans cette formule, R représente un amino ou un hétérocycle éventuellement substitué par un à quatre groupes alkyle inférieur; Ar représente un groupe phényle, naphtyle ou un hétérocycle aromatique portant éventuellement un à quatre substituants. Ces composés sont d'excellents médicaments, efficaces pour inhiber le néovascularisation et utiles pour traiter des tumeurs solides, les rhumatismes, la rétinopathie diabétique et le psoriasis.

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