Novel activin receptor and uses thereof

Details Novel activin receptor and uses thereof Novel activin receptor and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01)

Patent

CA 2627200

The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also provided.

La présente invention concerne de nouveaux polypeptides de récepteur IIB5 d'activine capables de se lier et d'inhiber les activités de l'activine A, de la myostatine ou de GDF-11. Cette invention concerne également des polynucléotides, des vecteurs et des cellules hôtes capables de produire lesdits polypeptides de récepteur. En outre, cette invention concerne des compositions et des procédés pour traiter une atrophie musculaire, des troubles métaboliques et d'autres troubles.

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