C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/501 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 1/04 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) A61P 27/02 (2006.01) A61P 27/16 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 491/10 (2006.01) C07D 491/113 (2006.01)
Patent
CA 2445348
A compound which has a therapeutic effect based on chemokine inhibitory activity and is satisfactory as a medicine for oral administration. The compound is a benzylpiperidine derivative represented by the following formula (1), which was found to have chemokine inhibitory activity. The compound can have enhanced chemokine inhibitory activity and heightened stability in the blood. (1) [In the formula, the symbols are the same as defined in the description.]
L'invention porte sur un composé qui possède un effet thérapeutique fondé sur l'activité inhibitrice de la chimiokine et constitue un bon médicament par administration orale. Ce composé est un dérivé de benzylpiperidine représenté par la formule (1) et qui présente l'activité inhibitrice de la chimiokine. Ce composé peut également posséder une meilleure activité inhibitrice de la chimiokine et une stabilité accrue dans le sang. Dans la formule (1), les symboles sont tels que définis dans la description.
Higashi Hidemitsu
Kiuchi Masatoshi
Kuroita Takanobu
Kuwahara Shigeki
Takeda Shuuzou
Fetherstonhaugh & Co.
Mitsubishi Pharma Corporation
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