A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 9/66 (2006.01) A61K 38/09 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 47/30 (2006.01)
Patent
CA 2216371
Novel burst-free, sustained release biocompatible and biodegradable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.
Nouvelles microcapsules biocompatibles et biodégradables à libération prolongée sans éclatement pouvant être programmées afin de libérer leur noyau actif pendant des durées variables allant de 1 à 100 jours dans un environnement physiologique aqueux. Les microcapsules se composent d'un noyau de polypeptide ou d'un autre agent biologiquement actif encapsulé dans une matrice de copolymères de poly(lactide/glucolide), se présentant sous la forme d'un mélange de formes non coiffées (goupe carboxyle terminal libre) et de formes coiffées dont les rapports sont compris entre 100/0 et 1/99.
Friden Phil
Jeyanthi Ramasubbu
Mcqueen Charles E.
Reid Robert H.
Roberts F. Donald
Ridout & Maybee Llp
United States Government Represented By The Secretary Of The Arm
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