C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/60 (2006.01) A61K 31/451 (2006.01) A61K 31/4523 (2006.01) A61K 31/5377 (2006.01) A61P 9/00 (2006.01) A61P 13/10 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2688057
The present invention relates to piperidine-based renin inhibitor compounds having carboxylate or carboxylic acid terminal groups. The disclosed low molecular weight, orally active renin inhibitors are of non-peptide nature and have long duration of action. The compounds can be used in the treatment of cardiovascular events and renal insufficiency.
L'invention concerne des composés inhibiteurs de rhénine à base de pipéridine renfermant des groupes terminaux carboxylate ou acide carboxylique. Les inhibiteurs de rhénine de l'invention, qui possèdent un faible poids moléculaire et une activité orale, sont de nature non peptidique et exercent une action de longue durée. Les composés précités peuvent être utilisés dans le traitement d'événements cardiovasculaires et de l'insuffisance rénale.
Aspiotis Renee
Chen Austin
Dube Daniel
Gallant Michel
Grimm Erich L.
Merck Frosst Canada Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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