C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 271/06 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61P 25/16 (2006.01) A61P 43/00 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2708447
The present invention provides compounds represented by general formula (I): (see formula I) or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is halo-lower alkyl, lower acyl, halo-lower alkylcarbonyl, cycloalkylcarbonyl, optionally substituted arylcarbonyl, lower alkoxycarbonyl or the like; R4 is lower alkyl, halo-lower alkyl, cycloalkyl, lower alkoxy-lower alkyl or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
L'invention porte sur un composé représenté par la formule générale (I) qui possède un effet inhibiteur puissant vis-à-vis de la COMT, ou un sel pharmacologiquement acceptable de celui-ci. L'invention porte également sur une composition pharmaceutique contenant le composé ou un sel pharmacologiquement acceptable de celui-ci, et sur les utilisations du composé, d'un sel pharmacologiquement acceptable du composé et de la composition pharmaceutique. [Dans la formule (I), R1 et R2 représentent respectivement un hydrogène, un acyle inférieur, un alcoxycarbonyle inférieur ou similaire R3 représente un alkyle inférieur halogéné, un acyle inférieur, un (alkyle inférieur)carbonyle halogéné, un cycloalkylcarbonyle, un arylcarbonyle facultativement substitué, un alcoxycarbonyle inférieur ou similaire; et R4 représente un alkyle inférieur, un alkyle inférieur halogéné, un cycloalkyle, un (alcoxy inférieur)(alkyle inférieur) ou similaires.]
Inoue Hitoshi
Ishikawa Takehiro
Kobayashi Satoko
Shiohara Hiroaki
Tanaka Nobuyuki
Kirby Eades Gale Baker
Kissei Pharmaceutical Co. Ltd.
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