C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/56 (2006.01) A61K 31/444 (2006.01) C07C 311/47 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2419841
The present invention relates to novel CD40:CD154 binding interruptor compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.
L'invention concerne de nouveaux composés interrompant la fixation entre CD40 et CD154 et l'utilisation de ces composés, ainsi que de compositions pharmaceutiques les contenant, afin de traiter des états associés à une activation inadéquate de CD154. Elle concerne, plus particulièrement, des composés qu'on identifie par criblage d'une banque de petites molécules, dans le but de rechercher les composés pouvant se fixer de façon spécifique à CD154 et d'interrompre l'interaction entre CD40 et CD154.
Carter Mary-Beth
Hsu Yen-Ming
Jindal Satish
Kirkovsky Leonid
Lenz George R.
Biogen Inc.
Biogen Idec Ma Inc.
Smart & Biggar
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