C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 501/56 (2006.01) A61K 31/545 (2006.01) A61K 31/675 (2006.01) A61K 31/69 (2006.01) A61K 31/695 (2006.01) C07D 501/00 (2006.01) C07F 5/02 (2006.01) C07F 7/10 (2006.01) C07F 9/547 (2006.01)
Patent
CA 2117679
Novel cephalosporin compounds of formula(I): Image wherein: R1 is a hydrogen or an amino protecting group; R2 and R3 are, independently, a hydrogen or a hydroxy protecting group, or form together a cyclic diol protecting group; R4 and R5 are, independently, a hydrogen or a carboxyl protecting group; X and Y are a nitrogen and a carbon atom, respectively, or a carbon and a nitrogen atom, respectively; R6 and R7 are, independently, a hydrogen or an amino, substituted amino, hydroxy, alkoxy, C1-4 alkyl, carboxyl or alkoxy carbonyl group, or jointly form a C3-7 cycloalkyl group together with the carbon to which they are attached, when X and Y are a nitrogen and a-carbon, respectively, or R7 is a hydrogen or an amino group when X and Y are a carbon and a nitrogen, respectively; and Q is =CH- or =N-, or pharmaceutically acceptable non-toxic salts, physiologically hydrolyzable esters, hydrates and solvates and isomers thereof, and isomers thereof possess potent and broad antibacterial activities.
Bang Chan S.
Jeon Jae H.
Kim Sam S.
Kim Se H.
Kim Yong Z.
Cassan Maclean
Lucky Limited
LandOfFree
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