Novel compound with platelet aggregation inhibitor activity

Details Novel compound with platelet aggregation inhibitor activity Novel compound with platelet aggregation inhibitor activity

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/195 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/55 (2006.01) C07C 237/24 (2006.01) C07C 257/16 (2006.01) C07C 257/18 (2006.01) C07C 279/14 (2006.01) C07C 279/16 (2006.01) C07D 211/34 (2006.01) C07D 211/62 (2006.01) C07D 263/14 (2006.01) C07D 263/32 (2006.01) C07D 413/06 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2136007

A compound represented by the general formula (I) and a pharmaceutically acceptable salt and solvate thereof having an effect for inhibiting the agglutination of platelets is disclosed: (see formula I) wherein R1 represents a group -W-(CH2)i-COOR3, R2 represents a hydrogen atom or a group -W-(CH2)i-COOR3 or - OR4, X represents -CH= or -N=, Y represents (i) a group -(CO)k-N(R5)-Z-, wherein Z represents a bond or a group -(CH2)m-CO- or a group -(CH2)m-CHR6-, (ii) a group -(CH2)m-N(R5)-(CO)k-, or (iii) a group -(CO)k-Het, wherein Het represents a five- or six- membered heterocyclic ring comprising a nitrogen atom, A represents (i) the following groups (II), (III) or (IV) Image B represents a bond, C1-6alkylene or C2-6alkenylen. 108

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