C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/14 (2006.01) A61K 31/4155 (2006.01) A61P 3/04 (2006.01) C07D 403/06 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2698704
The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3' R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.
La présente invention concerne de nouveaux composés thyroïdiens de formule (I), dans laquelle R1 R2, R3' R4 et Z sont tels que définis dans la description, leur procédé de préparation, une composition contenant de tels composés et l'utilisation de tels composés et de la composition en tant que médicament. En outre, les composés de formule (I) présentent une affinité de liaison nettement faible pour les récepteurs de thyroïde et sont donc considérablement exempts d'effets thyrotoxiques. L'invention concerne également l'utilisation des composés de formule (I) pour la préparation d'un médicament pour traiter diverses conditions morbides associées telles que l'obésité, la dyslipidémie, le syndrome métabolique et des comorbidités associées au syndrome métabolique.
Bhattamisra Subrat Kumar
Chauthaiwale Vijay
Chhipa Laxmikant
Dutt C.
Gupta Ramesh
Bcf Llp
Torrent Pharmaceuticals Ltd.
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