Novel compounds for the treatment of diseases associated...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 231/38 (2006.01) A61K 31/4155 (2006.01) A61K 31/427 (2006.01) A61K 31/444 (2006.01) A61P 25/28 (2006.01) C07D 213/74 (2006.01) C07D 277/42 (2006.01)

Patent

CA 2670418

The present invention relates to novel compounds of formula (II) that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid- like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating, or preventing diseases or conditions associated with amyloid and/or amyloid- like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid- like proteins is also disclosed.

L'invention concerne de nouveaux composés pouvant être utilisés dans le traitement d'un groupe de troubles et d'anomalies associé à la protéine amyloïde, notamment la maladie d'Alzheimer, et des maladies ou des troubles associés à des protéines de type amyloïde. Les composés de cette invention peuvent également être utilisés dans le traitement de maladies oculaires associées à des anomalies pathologiques/changements dans les tissus du système visuel. Elle concerne enfin des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés dans la préparation de médicaments destinés au traitement ou à la prévention de maladies ou de troubles associés à des protéines amyloïdes ou de type amyloïde. Un procédé de traitement ou de prévention des maladies ou des troubles associés à ces protéines est également décrit.

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