Novel compounds having antiviral activity

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 15/04 (2006.01) A61K 31/70 (2006.01) C07H 15/06 (2006.01) C07H 15/10 (2006.01) C07H 15/14 (2006.01) C07H 15/203 (2006.01)

Patent

CA 2255070

A compound or salt thereof comprises a mono-sach lipid, the lipid moiety being linked to the anomeric carbon of a nonulonic acid moiety by a glycosidic linkage or to the carbon at position 1 of a nonulonic acid moiety by an amide or ester linkage, and all the hydroxyl groups of the nonulonic acid moiety are sulphated. This compound has an antiviral activity with little anti coagulant activity and low cytotoxicity.

L'invention concerne des composés contenant des glycosides, dans lesquels un lipide est lié à la position 2 d'un acide sialique totalement sulfaté sur les groupes hydroxyles en position 7, 8 et 9, ou à l'acide 2-céto-3-désoxy-D-glycéro-2-nononique totalement sulfaté sur les groupes hydroxyles en position 4, 5, 7, 8 et 9, ou leurs sels. Ces composés ont une activité anti-rétrovirus, avec peu d'effet coagulant et peu de cytotoxicité.

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