Novel compounds, use thereof in cosmetic and cosmeceutic...

Details Novel compounds, use thereof in cosmetic and cosmeceutic... Novel compounds, use thereof in cosmetic and cosmeceutic...

C - Chemistry, Metallurgy

07

K

C07K 5/11 (2006.01) A61K 8/64 (2006.01) A61K 38/07 (2006.01) A61P 17/00 (2006.01) A61Q 19/08 (2006.01) C07K 5/10 (2006.01) C07K 5/113 (2006.01)

Patent

CA 2692190

A compound of the formula I: R-A-Gly-His-B (I) wherein: A and B are independently of each other a L-lysine residue, a D-lysine residue, or a L- or D- lysine residue in which the NH2 group of the side chain comprises a modification, wherein said modification is (i) a replacement with a hydrogen, (ii) an acetylation, (iii) a benzoylation, or (iv) a palmitoylation; Gly is a glycine residue; His is a L- or D-histidine residue; R is CH3-(CH2)n-CO-, wherein n = 2, 3, 4, 5, 6, 7 or 8; R' is a group of formula (II): N(Z)(Z') (II) wherein: Z and Z' is hydrogen, a methyl group, an ethyl group, a phenyl group, an hexyl group, a decyl group or an hexadecyl group; or a racemate, an enantiomer or a diastereomer thereof, or mixtures thereof, or a salt thereof.

L'invention porte sur un composé représenté par la formule (I): R-A-Gly-His-B (I) dans laquelle A et B sont indépendamment l'un de l'autre un reste L-lysine, un reste D-lysine ou un reste L- ou D-lysine dans lequel le groupe NH2 de la chaîne latérale comprend une modification, ladite modification étant (i) un remplacement par un hydrogène, (ii) une acétylation, (iii) une benzoylation, ou (iv) une palmitoylation; Gly est un reste glycine; His est un reste L- ou D-histidine; R est CH3-(CH2)n-CO-, où n = 2, 3, 4, 5, 6, 7 ou 8; R' est un groupe de formule (II): N(Z)(Z') (II) où Z et Z' représentent hydrogène, un groupe méthyle, un groupe éthyle, un groupe phényle, un groupe hexyle, un groupe décyle ou un groupe hexadécyle; ou un racémate, un énantiomère ou un diastéréomère de ce composé, ou leurs mélanges, ou un sel de ceux-ci.

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