Novel crystal forms of pyrrolylheptanoic acid derivatives

Details Novel crystal forms of pyrrolylheptanoic acid derivatives Novel crystal forms of pyrrolylheptanoic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2679317

The present invention provides novel crystalline forms D1 and D2 of [R-(R*,R* )]-2-(4- fluorophenyl)-.beta.,.delta.-dihydroxy-5-(l-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H- pyrrole- 1-heptanoic acid hemicalcium salt, and hydrates thereof. The crystalline forms D1 and D2 have X-ray powder diffraction peaks described in Figs. 1 and 3, respectively. Further, the present invention provides processes for preparing the crystalline forms and pharmaceutical compositions comprising the crystalline forms. The crystalline forms can be produced on a commercial scale and exhibit excellent stability.

La présente invention concerne des nouvelles formes cristallines D1 et D2 de sel d'hémicalcium d'acide [R-(R*,R* )]-2-(4- fluorophényl)-.beta.,.delta.-dihydroxy-5-(l-méthyléthyl)-3-phényl-4-[(phénylamino)carbonyl]-1H- pyrrole- 1-heptanoïque, et des hydrates de celles-ci. Les formes cristallines D1 et D2 présentent des pics de diffraction de rayons X sur poudres décrits dans les figures 1 et 3, respectivement. La présente invention concerne également des procédés de préparation desdites formes cristallines ainsi que des compositions pharmaceutiques comprenant lesdites formes cristallines. Les formes cristallines de l'invention peuvent être produites à l'échelle commerciale et présentent une excellente stabilité.

Affiliated with

Also associated with

Rating

Novel crystal forms of pyrrolylheptanoic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel crystal forms of pyrrolylheptanoic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel crystal forms of pyrrolylheptanoic acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1880033