Novel curcumin analogues and uses thereof

Details Novel curcumin analogues and uses thereof Novel curcumin analogues and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 307/58 (2006.01) A61K 31/121 (2006.01) A61K 31/341 (2006.01) A61P 5/28 (2006.01) A61P 35/00 (2006.01) C07C 49/255 (2006.01) C07D 231/12 (2006.01)

Patent

CA 2583943

The present invention relates to compounds capable of acting as androgen receptor, antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.

La présente invention concerne des composés pouvant agir comme récepteur des androgènes, des antagonistes, des préparations pharmaceutiques les contenant, ainsi que leurs méthodes d'utilisation. Ces utilisations incluent, entre autres, une utilisation comme agents antitumoraux, notamment pour le traitement de cancers tels que le cancer du côlon, de la peau et de la prostate, et visent à induire une activité antagoniste du récepteur des androgènes chez un sujet souffrant d'une affection associée aux androgènes. Les exemples d'affections associées aux androgènes comprennent, entre autres, la calvitie, l'hirsutisme, les troubles du comportement, l'acné et la spermatogenèse non inhibée dans le cas où une inhibition de la spermatogenèse est souhaitée.

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