C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/4166 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2631504
The invention relates to the novel products of formula (I): in which X1 and X2 represent: either one hydrogen and the other alkyl; or one -OCF3 or -SCF3 and the other NH-CO-alkyl-R3; or X1 and X2 form, with the phenyl radical to which they are attached, an optionally substituted dihydro-indole radical; R represents pyridyl or pyrimidinyl substituted with NR1R2, with R1 representing hydrogen or alkyl, and R2 representing optionally substituted alkyl, cycloalkyl, heterocycloalkyl, phenyl, pyrimidinyl, pyridyl, and CO-R3 with R3 representing in particular amine, alkoxy, heterocycloalkyl, aryl, aryloxy and heteroaryl; all these radicals being optionally substituted; and salts thereof.
L'invention concerne les nouveaux produits de formule (I) : dans laquelle X1 et X2 représentent : soit l'un hydrogène et l'autre alkyle; soit l'un -OCF3 ou -SCF3et l'autre NH-CO-alkyl-R3; soit X1 et X2 forment avec le radical phényle auquel ils sont liés un radical di-hydroindole éventuellement substitué; R représente pyridyle ou pyrimidinyle substitués par NR1R2, avec R1 représente hydrogène ou alkyle, et R2 représente alkyle éventuellement substitué, cycloalkyle, hétérocycloalkyle, phényle, pyrimidinyle, pyridyle, et CO-R3 avec R3 représente notamment amine, alcoxy, hétérocycloalkyle, aryle, aryloxy et hétéroaryle; tous ces radicaux étant éventuellement substitués; et leurs sels.
Certal Victor
Dagallier Anne
El-Ahmad Youssef
Halley Frank
Ritter Kurt
Aventis Pharma S.a.
Robic
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