C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) C07D 209/34 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 451/14 (2006.01)
Patent
CA 2559143
The invention relates to cycloalkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claims 1 to 6, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
La présente invention concerne des 5-acylindolinones à teneur en cycloalkyle de formule générale (I) dans laquelle R1 à R3 sont tels que définis dans les revendications 1 à 6, leurs tautomères, leurs énantiomères, leurs diastéréomères, leurs mélanges et leurs sels, qui ont des propriétés pharmacologiques intéressantes, notamment une action d'inhibition sur des protéine kinases, en particulier sur l'activité de la glycogène-synthase-kinase (GSK-3).
Heckel Armin
Hoerer Stefan
Kley Joerg
Roth Gerald Juergen
Uphues Ingo
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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