C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 7/10 (2006.01) A61K 31/196 (2006.01) A61P 25/28 (2006.01) C07C 45/27 (2006.01) C07C 47/277 (2006.01) C07C 205/37 (2006.01) C07C 205/59 (2006.01) C07C 205/60 (2006.01) C07C 227/04 (2006.01) C07C 229/64 (2006.01) C07D 333/20 (2006.01)
Patent
CA 2155666
The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of general formula (I) wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula (I) wherein R1 and R2 = H, X = Br and Y = Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3- HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.
Bjork Susanna Karin Maria
Carpenter Barry K.
Gotthammar Kristina Brigitta
Linderberg Mat Torbjorn
Luthman Per Johan
Astra Aktiebolag
Cornell Research Foundation Inc.
Fetherstonhaugh & Co.
The University Of Maryland
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