Novel dnas and process for producing proteins by using the same

Details Novel dnas and process for producing proteins by using the same Novel dnas and process for producing proteins by using the same

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2235148

DNAs represented by Sequence Listings (1 and 2) and a process for producing proteins which comprises inserting these DNAs into expression vectors to thereby produce proteins having molecular weights of about 60 kD (under reductive conditions) and about 60 kD and about 120 kD (under nonreductive conditions) and being capable of inhibiting the formation of osteoclasts. These proteins are useful in the treatment of osteoporosis and rheumatism.

Cette invention concerne de nouveaux ADN qui correspondent aux listes de séquences 1 et 2. Cette invention concerne également un procédé de production de protéines, lequel consiste à insérer ces ADN dans des vecteurs d'expression de manière à produire des protéines qui possèdent des poids moléculaires d'environ 60 kD dans des conditions de réduction, et d'environ 60 à 120 kD dans des conditions de non-réduction. Ces protéines sont capables d'inhiber la formation d'ostéoclastes, et sont utiles dans le traitement de l'ostéoporose et des rhumatismes.

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