A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) A61K 49/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/15 (2006.01) C12N 15/24 (2006.01) C12N 15/52 (2006.01) C12N 15/55 (2006.01) C12N 15/57 (2006.01) C12N 15/85 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2562482
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 or PRO1480 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
L'invention concerne des animaux transgéniques, ainsi que des compositions et des méthodes associées se rapportant à la caractérisation de la fonction génique. L'invention concerne en particulier des souris transgéniques présentant des disruptions dans les gènes PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 ou PRO1480. Ces études et caractérisations in vivo permettent de découvrir ou d'identifier de manière fiable des agents thérapeutiques et/ou des traitements utiles dans la prévention, l'atténuation ou le traitement de maladies ou dysfonctionnements associés à des disruptions géniques, tels que les troubles neurologiques, les troubles cardiovasculaires, endothéliaux ou angiogéniques, les anomalies oculaires, les troubles immunologiques, les troubles oncologiques, les anomalies ou troubles métaboliques osseux, les troubles métaboliques lipidiques ou les troubles de croissance.
Brennan Jane
Desauvage Frederic
Edwards Joel
Filvaroff Ellen
Grewal Iqbal
Genentech Inc.
Lexicon Genetics Incorporated
Lexicon Pharmaceuticals Inc.
Smart & Biggar
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