C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 38/48 (2006.01) A61K 38/49 (2006.01) A61P 7/02 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2141842
The present invention relates to novel glycoforms and preparations of the soluble complement receptor type 1(sCRI), and their uses in the therapy of comple-ment mediated diseases and disorders involving inflam-mation and inappropriate complement activation and in thrombotic or shock state conditions. The invention provides novel glycoforms and methods for producing, detecting, enriching and purifying such glycoforms. The invention further provides methods of specifically prod-ucing a glycoform by recombinant or chemical means. Preferred embodiments of the invention include sialy-lated glycoforms and glycoforms with a pI <= 5.1 deter-mined by chromatofocusing or with a sialic acid to mannose molar ratio of >= 0.25. The glycoforms may be formulated alone in therapeutic compositions or in combination with thrombolytic agents.
Freeman Anne Mary
Gosselin Michael L.
Lifter John
Marsh Henry C. Jr.
Smith Richard A. G.
Celldex Therapeutics Inc.
Osler Hoskin & Harcourt Llp
Smithkline Beecham P.l.c.
T. Cell Sciences Inc.
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