Novel heterocyclic compound and medicinal use thereof

Details Novel heterocyclic compound and medicinal use thereof Novel heterocyclic compound and medicinal use thereof

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/4725 (2006.01) C07D 217/26 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2448634

A novel heterocyclic compound which is either one represented by the formula (I): (I) {wherein R1 represents hydrogen or C1-6 alkyl; R2 represents hydrogen, -CO-C(R4)=C(R4)-R5 (wherein R4 is hydrogen or C1-4 alkyl and R5 is C4-8 alkyl, C2-8 alkenyl, etc.), etc.; Y represents a group represented by (II) [wherein X is oxygen or sulfur; R7 has the same meaning as R4; R8 is R10- C(R9)=C(R9)- (wherein R9 has the same meaning as R4 and R10 is C3-6 alkyl, etc.), etc.; R14 has the same meaning as R4; and R15 represents aryl, etc.]; Y- (CH2)n-O- is bonded to the 6- or 7-positon carbon atom of the tetrahydroisoquinoline skeleton; and n is an integer of 1 to 4} or a pharmaceutically acceptable salt thereof. The compound (I) is useful as an antihyperglycemic agent, antihyperlipemic agent, insulin resistance ameliorant, diabetes remedy, remedy for complications of diabetes, glucose tolerance insufficiency ameliorant, antiarteriosclerotic agent, antiobestic agent, anti-inflammatory agent, preventive/remedy for diseases attributable to PPAR, and preventive/remedy for X syndrome.

La présente invention concerne un nouveau composé hétérocyclique qui est représenté par la formule (I) : {où R¿1? représente hydrogène ou alkyle C¿1-6? ; R¿2? représente hydrogène, -CO-C(R?4¿) = C (R?4¿)-R?5¿ (où R?4¿ est hydrogène ou alkyle C¿1-4 ?et R?5¿ est alkyle C¿4-8?, alcényle C¿2-8?, etc.), etc. ; Y représente un groupe représenté par (II) [où X est oxygène ou soufre ; R?7¿ a la même signification que R?4¿ ; R?8¿ est R?10¿-C(R?9¿) = C(R?9¿)(où R?9¿ a la même signification que R?4¿ et R?10¿ est alkyle C¿3-6?, etc.), etc. ; R?14¿ a la même signification que R?4¿ ; et R?15¿ représente aryle, etc. ] ; Y-(CH¿2?)¿n?-O- est lié à l'atome de carbone en position 6 ou 7 du squelette de tétrahydroisoquinoline ; et n est un entier compris entre 1 et 4} ou un sel pharmaceutiquement acceptable. Le composé (I) est utile en tant qu'agent antihyperglycémique, agent antihyperlipémique, améliorant de résistance à l'insuline, médicament contre le diabète, médicament contre des complications du diabète, améliorant de l'insuffisance à la tolérance au glucose, agent antiartériosclérotique, agent antiobésité, agent antiinflammatoire, agent de prévention/médicament contre les maladies imputables au récepteur activé par un proliférateur du peroxysome, et agent de prévention/médicament contre le syndrome X.

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