Novel hsp90 inhibitor

Details Novel hsp90 inhibitor Novel hsp90 inhibitor

C - Chemistry, Metallurgy

07

D

C07D 249/12 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2598899

Disclosed is a triazole derivative represented by the general formula (1) below or a pharmacologically acceptable salt thereof. Also disclosed are a prodrug of such a triazole derivative and an HSP90 inhibitor containing any one of them as an active constituent. (1) (In the formula, X represents a halogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group or the like; Y represents a mercapto group, a hydroxyl group, an optionally substituted sulfonyl group, an optionally substituted amino group or the like; and R represents an optionally substituted aryl or amino group or the like.)

Cette invention concerne un dérivé de triazole représenté par la formule générale (1) ci-dessous ou un sel pharmaceutiquement acceptable de ce dérivé. L'invention concerne également un promédicament d'une tel dérivé de triazole et un inhibiteur de HSP90 contenant l'un deux comme principe actif. (1). (Dans cette formule, X représente un atome d'halogène, un groupe alkyle éventuellement substitué ou analogue; Y représente un groupe mercapto, un groupe hyddroxyle, un groupe sulfonyle éventuellement substitué, un groupe amino éventuellement substitué ou analogue; et R représente un groupe aryle ou un groupe amino éventuellement substitué ou analogue.)

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