C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/404 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61P 11/00 (2006.01) C07D 209/22 (2006.01) C07D 209/42 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2505988
The invention relates to substituted 4- or/and 7-hydroxyindoles of formula (I), method for production thereof, pharmaceutical preparations comprising said compounds and the pharamceutical use of said compounds, which are inhibitors of phosphodiesterase 4, as agents for the treatment of diseases which can be influenced by said compounds by means of an inhibition of the phosphodiesterase 4 activity in immunocompetent cells (for example, macrophages and lymphocytes).
L'invention concerne des 4- et/ou 7-hydroxyindoles substitués de formule (I), des procédés de production desdits composés, des préparations pharmaceutiques contenant ces composés ainsi que l'utilisation pharmaceutique de ces composés, inhibiteurs de la phosphodiestérase 4, comme principes actifs dans le traitement de maladies nécessitant une inhibition de l'activité de la phosphodiestérase 4 dans des cellules immunocompétentes (p. ex. macrophages et lymphocytes) par les composés de la présente invention.
Egerland Ute
Gasparic Antje
Hartenhauer Helge
Hoefgen Norbert
Kuss Hildegard
Elbion Ag
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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