Novel insulin derivatives having an extremely delayed...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/62 (2006.01)

Patent

CA 2711749

The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.

L'invention concerne de nouveaux analogues d'insuline à profil temporel/d'action basal, caractérisés en ce que a) la fin de chaîne B est composée d'un radical aminoacide basique amidé tel que lysine ou argininamide, b) le radical aminoacide N-terminal de la chaîne A de l'insuline est un radical lysine ou arginine, c) la position A8 de l'aminoacide est occupée par un radical histidine, d) la position A21 de l'aminoacide est occupée par un radical glycine, et e) une ou plusieurs substitutions et/ou additions de radicaux aminoacide chargés négativement ont eu lieu dans les positions A5, A15, A18, B-1, B0, B1, B2, B3 et B4.

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