Novel intermediate and process for preparing entecavir using...

Details Novel intermediate and process for preparing entecavir using... Novel intermediate and process for preparing entecavir using...

C - Chemistry, Metallurgy

07

D

C07D 473/18 (2006.01)

Patent

CA 2747777

The present invention relates to a novel, high-yield and low-cost method for preparing entecavir, [1-S- (1.alpha.,3.alpha.,4,.beta.]-2-amino -1,9-dihydro-9-[4-hydroxy-3- (hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one, an antiviral agent, and novel intermediates used therein.

La présente invention concerne un nouveau procédé peu onéreux et à grand rendement pour la préparation d'entécavir, [1-S-(1a,3a,4,ß]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxyméthyl)-2-méthylènecyclopentyl]-6H-purin-6-one, un agent antiviral, et les nouveaux intermédiaires utilisés dans ce procédé.

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