Novel isoquinoline derivatives

Details Novel isoquinoline derivatives Novel isoquinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 217/02 (2006.01) C07D 217/22 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2234051

The present invention aims to provide new compounds having inhibitory activity of apoptotic neuronal cell death, and new isoquinoline derivatives and pharmaceutically acceptable acid addition salts represented by the following general formula (I) are obtained. (see formula I) wherein Ar shows an aromatic ring which may be substituted, and n shows 0, 1 or 2. The compounds of the present invention have inhibitory activity of neuronal cell death, and they are useful for agents of prevention and treatment of neuronal neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's chorea and amyotrophic lateral sclerosis, cerebral ischemic injury such as stroke, and peripheral neuropathy in diabetes mellitus.

Cette invention a trait à des dérivés d'isoquinoléine représentés par la formule générale suivante (I) ou à leurs sels d'addition d'acide, acceptables d'un point de vue pharmaceutique, destinés à l'élaboration de nouveaux composés dotés d'une action inhibitrice sur la mort, de type apoptotique, de la cellule nerveuse. Dans cette formule, Ar représente un noyau aromatique éventuellement substitué et n vaut 0, 1 ou 2. Du fait de leur action inhibitrice sur la mort cellulaire, ces composés se révèlent des plus utiles en tant qu'agents de prévention et remèdes s'agissant de maladies neurodégénératives, des maladies d'Alzheimer et de Parkinson, de la chorée de Huntington et de la sclérose latérale amyotrophique notamment, ainsi que de maladies ischémiques cérébrales, telle que l'attaque cérébrale, et de troubles du nerf périphérique que l'on observe chez des diabétiques, etc.

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