C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/04 (2006.01) C07D 217/10 (2006.01)
Patent
CA 2685488
The present invention provides novel isoquinolinium compounds, methods of producing the isoquinolinium compounds, and methods for converting them into cisatracurium, e.g., cisatracurium besylate. The isoquinolinium compounds of the present invention can be obtained in the form of solids, which can be purified using simple techniques and can be used to afford pure cisatracurium besylate without HPLC purification
La présente invention porte sur de nouveaux composés d'isoquinolinium, sur des procédés de fabrication des composés d'isoquinolinium, et sur des procédés de transformation de ces derniers en cisatracurium, par exemple en bésylate de cisatracurium. Les composés d'isoquinolinium de la présente invention peuvent être obtenus sous forme solide, pouvant être purifiée à l'aide de techniques simples, et peuvent être utilisés pour fournir du bésylate de cisatracurium pur sans purification par HPLC.
Arad Oded
Hongli Guo
Jingshan Shen
Klopfer Eyal
Naddaka Vladimir
Chemagis Ltd.
Ridout & Maybee Llp
LandOfFree
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