C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/67 (2006.01) A61K 31/166 (2006.01) A61K 31/396 (2006.01) A61K 31/661 (2006.01) A61P 35/00 (2006.01) C07C 301/00 (2006.01) C07C 317/36 (2006.01) C07D 203/14 (2006.01) C07F 9/09 (2006.01)
Patent
CA 2544335
The present invention relates to novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy (GDEPT) and antibody-directed enzyme~prodrug therapy (ADEPT), in conjunction with nitroreductase enzymes.
La présente invention concerne une nouvelle moutarde nitrophényle et de nouveaux alcools nitrophénylaziridine, leurs phosphates correspondants et leur utilisation en tant qu'agents cytotoxiques ciblés, en tant que médicaments bioréducteurs dans les tumeurs hypoxiques et concerne également leur utilisation pour effectuer l'ablation cellulaire, y compris la thérapie génique enzyme-promédicament (GDEPT) et la thérapie enzyme-promédicament vectorisé par anticorps (ADEPT), conjointement aux enzymes nitroréductase.
Atwell Graham John
Denny William Alexander
Helsby Nuala Ann
Patterson Adam Vorn
Wilson William Robert
Auckland Uniservices Limited
Sim & Mcburney
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