Novel peptides

Details Novel peptides Novel peptides

C - Chemistry, Metallurgy

07

K

C07K 7/56 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/58 (2006.01) C07K 14/705 (2006.01) C07K 14/745 (2006.01) C07K 16/40 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2149783

ABSTRACT The present invention provides peptides represented by the following formula (A): Image (A) wherein Q represents a physiologically active peptide moiety; X each represents the same or different .alpha.-amino acid residue; M represents Gly or Cys; m represents an integer of from 5 to 8; and n represents an integer of from 0 to 3, or their pharmaceutically acceptable salts thereof. The peptides of the present invention have higher stability and/or higher activity than physiologically active linear peptides to which no cyclic peptide is bonded.

Peptide représenté par la formule générale (I) ou sel de ce composé acceptable en pharmacologie. Dans la formule, Q représente un reste de peptide physiologiquement actif; Xs représente les restes du même alpha -aminoacide ou d'aminoacides différents; M représente Gly ou Cys; et m et n représentent de nombres entiers compris, respectivement, entre 5 et 8 et entre 0 et 3. Ce peptide présente une plus grande stabilité et/ou une plus grande activité que les peptides à chaîne droite à action physiologique ne possédant pas de liaisons peptidiques cycliques.

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