Novel polypeptides and use thereof

Details Novel polypeptides and use thereof Novel polypeptides and use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/31 (2006.01) A61K 31/16 (2006.01)

Patent

CA 2649589

The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus ('CHIPS'), the polypeptide comprising a variant of the amino acid sequence of SEQ ID NO:1. Preferably, the polypeptide is a CHIPS variant wherein one or more of the following amino acids is modified: N31, S32, G33, L34, P35, K40, D42, R46, Y48, K50, G52, T53, K54, N55, S56, A57, Q58, K61, E67, K69, L76, N77, P79, D83, L90, K92, K100, K101, S104, K105, S107, Y108, N111 and G112. In a preferred embodiment, the polypeptide is less immunogenic hi humans than the wildtype CHIPS protein. The invention further provides methods of making and using such variant CHIPS polypeptides.

L'invention concerne un polypeptide présentant une activité biologique de la protéine CHIPS (Chemotaxis Inhibitory Protein of Staphylococcus aureus), ce polypeptide comprenant un variant de la séquence d'acides aminés de SEQ ID NO:1. De préférence, ledit polypeptide est un variant de la protéine CHIPS dans lequel un ou plusieurs des acides aminés suivants sont modifiés : N31, S32, G33, L34, P35, K40, D42, R46, Y48, K50, G52, T53, K54, N55, S56, A57, Q58, K61, E67, K69, L76, N77, P79, D83, L90, K92, K100, K101, S104, K105, S107, Y108, N111 et G112. Dans un mode de réalisation préféré, le polypeptide est moins immunogène chez des humains que la protéine CHIPS de type sauvage. L'invention concerne en outre des méthodes de production et d'utilisations desdits polypeptides variants de la protéine CHIPS.

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