C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/54 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2470012
The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
L'invention concerne de nouveaux polynucléotides isolés et de nouveaux polypeptides cibles à petites molécules codés par lesdits polynucléotides. Elle concerne également des anticorps qui se lient de manière immunospécifique à un nouveau polypeptide cible à petites molécules ou un dérivé, variant, mutant ou fragment quelconque dudit polypeptide, polynucléotide ou anticorps. Elle concerne en outre des procédés selon lesquels ledit polypeptide à petites molécules, ledit polynucléotide et ledit anticorps sont utilisés pour la détection et le traitement d'une large gamme d'états pathologiques. De manière plus spécifique, l'invention concerne des procédés pour utiliser des protéines exprimées de manière recombinée et/ou de manière endogène dans différentes procédures de criblage servant à identifier des anticorps thérapeutiques et de petites molécules thérapeutiques associés à des maladies. L'invention concerne en outre des méthodes thérapeutiques, diagnostiques et des méthodes de recherche pour le diagnostic, le traitement et la prévention de troubles dans lesquels intervient n'importe lequel de ces nouveaux acides nucléiques et protéines humains.
Anderson David W.
Ballinger Robert A.
Baumgartner Jason C.
Berghs Constance
Burgess Catherine E.
Curagen Corporation
Na
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