C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2449341
The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
L'invention concerne des nouveaux polynucléotides isolés et des polypeptides cibles de petites molécules codés par lesdits polynucléotides. Elle concerne également des anticorps qui se fixent de manière immunospécifique sur un nouveau polypeptide cible de petites molécules ou sur tout dérivé, variant, mutant ou fragment dudit polypeptide, polynucléotide ou anticorps, ainsi que des méthodes utilisant lesdits polypeptides cibles de petites molécules, polynuléotide ou anticorps pour la détection et le traitement d'un grand nombre d'états pathologiques. L'invention concerne plus particulièrement des méthodes d'utilisation de protéines exprimées par recombinaison et/ou de manière endogène dans diverses techniques de criblage, pour identifier des anticorps thérapeutiques et des petites molécules thérapeutiques associés à des maladies. L'invention concerne en outre des méthodes thérapeutiques, diagnostiques et de recherche mises en oeuvre pour diagnostiquer, traiter ou prévenir des troubles impliquant l'un quelconque de ces nouveaux acides nucléiques et protéines humaines.
Agee Michele L.
Anderson David W.
Berghs Constance
Boldog Ferenc L.
Burgess Catherine E.
Curagen Corporation
Ridout & Maybee Llp
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