Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

Details Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2555345

In its many embodiments, the present invention provides pyrazolo[1,5- a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

Dans un bon nombre de modes de réalisation, on prévoit une nouvelle classe de composés pyrazolo[1,5-a]pyrimidine tenant lieu d'inhibiteurs de kinase dépendant de la cycline, des procédés de tels composés, de compositions pharmaceutiques contenant un ou plusieurs composés, de procédés de préparations de formulations pharmaceutiques comprenant un ou plusieurs des composés et des méthodes de traitement, de prévention, d'inhibition ou d'amélioration d'une ou plusieurs maladies associées aux CDK utilisant de tels composés ou compositions pharmaceutiques.

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