Novel pyridazinone derivatives as inhibitors of cdk2

Details Novel pyridazinone derivatives as inhibitors of cdk2 Novel pyridazinone derivatives as inhibitors of cdk2

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/501 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2567154

The present invention relates to compounds according to the general formula (I), with the definitions of the substituents X, R1 and R2 given below in the text, as well as their physiologically acceptable salts, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).

L'invention a trait à des composés représentés par la formule générale (I), les substituants X, R?1¿ et R?2¿ étant définis dans le descriptif, et à leurs sels physiologiquement acceptables, à des procédés de production de ces composés et à leur utilisation comme agents pharmaceutiques. Ces composés constituent des inhibiteurs de kinase, en particulier des inhibiteurs de la kinase CDK2 (kinase 2 dépendant des cyclines).

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